Identification of an Essential Francisella tularensis subsp. tularensis Virulence Factor
نویسندگان
چکیده
منابع مشابه
Identification of an essential Francisella tularensis subsp. tularensis virulence factor.
Francisella tularensis, the highly virulent etiologic agent of tularemia, is a low-dose intracellular pathogen that is able to escape from the phagosome and replicate in the cytosol. Although there has been progress in identifying loci involved in the pathogenicity of this organism, analysis of the genome sequence has revealed few obvious virulence factors. We previously reported isolation of a...
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One of the most fundamental aspects of infectious diseases is microbial acquisition of nutrients in vivo, which impacts virulence and antibiotic treatment. Therefore, it is not surprising that part of the innate host defense against microbial infection is to limit access of various invading pathogens to sources of host nutrients (Abu Kwaik and Bumann, 2013; Eisenreich et al., 2013). Despite thi...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2009
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.01113-08